New York University · BiologyThe Hox Epigenetics Lab
Esteban Orlando Mazzoni · New York, New York
Research Focus
Esteban Mazzoni's lab at NYU School of Medicine focuses on understanding how Hox genes, which are essential for the body's development, maintain their positional identity through epigenetic memory. The lab investigates how different signaling factors interact with chromatin to properly activate or repress these genes during cell differentiation. This research has implications for understanding developmental processes and diseases such as cancer.
Hox genesepigenetic memorychromatincell differentiationpolycombretinoic acidsynthetic DNAgene regulationcancer mechanismsdevelopmental biology
Research Aims
5AIM 01Investigate how retinoic acid signaling influences Hox gene activation and repression.
AIM 02Identify the mechanisms behind Polycomb Repressive Complex recruitment to Hox genes.
AIM 03Explore the role of CTCF in chromatin boundary formation.
AIM 04Develop synthetic DNA tools to create Hox regulatory units.
AIM 05Understand the relationship between Hox genes and cellular positional identity.
Skills the Lab Values
chromatin immunoprecipitation (ChIP)synthetic DNA constructionstem cell cultureCRISPR gene editinggene expression analysisPCRcell lineage tracingWestern blot analysisRNA sequencingmicroscopy
Output against the department
Publications87bottom 28% of dept.734th of 1,033
this lab
most publishedleast published
Citations5.0kbottom 38% of dept.636th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.