University of North Texas Health Science Center · Microbiology & ImmunologyChlamydia Vaccine Research Group
Guangming Zhong · Fort Worth, Texas
Research Focus
Dr. Guangming Zhong's lab focuses on developing an innovative oral vaccine to prevent Chlamydia trachomatis, a common sexually transmitted infection. They are researching a specific strain of Chlamydia muridarum that can safely stimulate the immune system without causing disease. The lab's work aims to establish effective immunization strategies that could lead to clinical trials for this vaccine, significantly impacting public health.
Chlamydia trachomatisoral vaccinetransmucosal immunityChlamydia muridarumsexually transmitted infectionsvaccine developmentimmune response
Research Aims
5AIM 01Develop an oral vaccine against Chlamydia trachomatis using Chlamydia muridarum.
AIM 02Evaluate the efficacy of the vaccine in animal models.
AIM 03Identify protective immune correlates and key CT antigens.
AIM 04Investigate the mechanisms of transmucosal immunity induced by the vaccine.
AIM 05Prepare for clinical trials by generating IND-enabling data.
Skills the Lab Values
animal modelsvaccine formulationimmunology techniquesantigen presentationcell culturePCRbiological assaysdata analysismouse handlingclinical trial design
Output against the department
Publications269top 20% of dept.97th of 486
this lab
most publishedleast published
Citations11ktop 34% of dept.167th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.