University of Michigan-Ann Arbor · NeuroscienceUbiquitin Dynamics Lab
Henry L Paulson · Ann Arbor, Michigan
Research Focus
Dr. Henry L. Paulson's lab at the University of Michigan focuses on understanding the mechanisms behind age-related neurodegenerative diseases, especially how proteins involved in cellular quality control, such as ubiquitin, contribute to these disorders. The lab aims to discover new treatments by studying how these proteins become dysfunctional and lead to diseases like Alzheimer's and Huntington's. By investigating the complex biology of these proteins, the research seeks to identify potential therapeutic targets.
neurodegenerative diseasesubiquitin pathwayspolyglutamineprotein aggregationtherapeutic targetsquality control pathwaysneuron function
Research Aims
5AIM 01Investigate how ubiquitin signaling gets disrupted in neurodegenerative diseases.
AIM 02Understand the role of protein aggregation in the toxicity of neurons.
AIM 03Explore the relationship between mutations in proteins and their phase transitions.
AIM 04Identify new therapeutic targets for treating neurodegenerative disorders.
AIM 05Utilize innovative models to study age-related neurodegeneration.
Skills the Lab Values
cell cultureprotein extractionWestern blotphase separation analysisRNA sequencingmouse modelsimmunohistochemistrybioinformaticsmodeling disease mechanisms
Output against the department
Publications417top 14% of dept.96th of 671
this lab
most publishedleast published
Citations34ktop 11% of dept.73rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.