UTHThe University of Texas Health Science Center at Houston · Biochemistry
Jayaraman Lab
Vasanthi Jayaraman · Houston, Texas
Research Focus
Dr. Vasanthi Jayaraman's lab focuses on understanding how different types of glutamate receptors work in the brain, especially in relation to controlling movement and cognitive functions such as learning and memory. By using advanced techniques like single-molecule FRET and various biochemical methods, the lab investigates the complex interactions and structural changes within these receptors, aiming to uncover how they operate in both healthy and disease conditions. Their work could provide insights into the mechanisms underlying neurological disorders like strokes and Parkinson's disease.
glutamate receptorsion channelsneurobiologysingle-molecule FRETsynaptic transmissionneurological disordersreceptor modulationbiochemical imaging
Research Aims
5AIM 01Investigate the activation mechanisms of NMDA and AMPA glutamate receptors.
AIM 02Explore the structure-function relationships of various glutamate receptor subtypes.
AIM 03Examine the activation and modulation of kainate receptors by different ligands.
AIM 04Understand the role of delta receptors in synaptic contexts.
AIM 05Utilize advanced imaging techniques to reveal conformational changes in receptors.
Skills the Lab Values
single-molecule FRETelectrophysiologybiochemical assaysfluorescence microscopycomputational modelingprotein purificationdata analysisimmunofluorescencecell culture
Output against the department
Publications180top 47% of dept.188th of 402
this lab
most publishedleast published
Citations3.5kbottom 17% of dept.333rd of 402
this lab
most citedleast cited
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