University of California-San Francisco · NeuroscienceClelland Gene Lab
Claire Clelland · San Francisco, California
Research Focus
Dr. Claire Clelland's lab at UCSF focuses on innovative approaches to address neurological diseases through advanced gene therapy techniques. They develop and test new methods to deliver treatments directly to the central nervous system (CNS) using ethically sourced human cadaver models. Additionally, their work involves utilizing CRISPR technology to target and edit genes associated with conditions like frontotemporal dementia, aiming to create effective therapeutic options for patients.
gene therapyCRISPRcentral nervous systemfrontotemporal dementianeurodegenerative diseasesdelivery vectorshuman cadaversMAPT mutationtauopathiesbiologics
Research Aims
5AIM 01Develop efficient gene delivery vectors for CNS diseases using human cadavers.
AIM 02Optimize CRISPR strategies to excise mutant MAPT alleles in patients' cells.
AIM 03Evaluate the potential of CRISPR to reverse neurodegenerative pathology in mouse models.
AIM 04Investigate the effects of regulatory genes on MAPT function and expression.
AIM 05Create a reliable platform for future gene therapy applications in human patients.
Skills the Lab Values
CRISPR/Cas9 genome editingcell culturegene editing in iPSCsmouse models for FTDvector delivery optimizationAAV vector technologypharmacokineticspreclinical testingethics in researchbiological data analysis
Output against the department
Publications44bottom 9% of dept.609th of 671
this lab
most publishedleast published
Citations2.6kbottom 17% of dept.558th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.