University of Arizona · PharmacologyNaphthalene Toxicology Lab
Xinxin Ding · Tucson, Arizona
Research Focus
Dr. Xinxin Ding's lab at the University of Arizona studies the harmful effects of naphthalene, a common pollutant found in smoke and vehicle exhaust, particularly focusing on how it can cause lung damage and cancer. The lab investigates how naphthalene is processed in the body, especially in the liver, and how these processes lead to toxic effects in the lungs. Their work aims to better understand the risk factors associated with exposure to this chemical and to find ways to monitor its effects on human health.
naphthalenetoxicologylung cancerbioactivationcytochrome P450DNA adductsmetabolite transportfirefighter exposurepublic healthcarcinogenesis
Research Aims
4AIM 01Investigate how liver-generated metabolites of naphthalene contribute to lung toxicity.
AIM 02Understand the mechanisms by which naphthalene induces DNA damage in lung tissue.
AIM 03Explore the role of serum albumin in transporting naphthalene metabolites to the lungs.
AIM 04Characterize naphthalene metabolites and DNA adduct profiles in exposed human populations.
Skills the Lab Values
DNA adduct characterizationmouse modelsbiochemical assayscell culture techniquesmetabolite profilingdrug administration methodsbiomarker analysisstatistical analysistoxicokinetic studiesanalytical chemistry techniques
Output against the department
Publications320top 24% of dept.110th of 462
this lab
most publishedleast published
Citations9.0ktop 42% of dept.196th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.