MUSMedical University of South Carolina · Biochemistry
Metallothionein Cancer Research Lab
Joe R Delaney · Charleston, South Carolina
Research Focus
Dr. Joe R. Delaney's research at the Medical University of South Carolina focuses on understanding how certain genetic changes in tumors can affect their behavior and response to treatment. Specifically, his lab investigates a group of proteins called metallothioneins, which are involved in regulating metals in cells and can influence tumor development, especially in ovarian cancer. This research aims to find new ways to target these genetic vulnerabilities in cancer cells, ultimately leading to improved therapies for patients.
aneuploidymetallothioneinsovarian cancertumor suppressorscancer therapeutics
Research Aims
4AIM 01Characterize the effects of metallothionein gene loss in ovarian cancer development.
AIM 02Develop models to control the suppression of metallothioneins.
AIM 03Identify the molecular pathways regulated by metallothioneins that act as tumor suppressors.
AIM 04Discover drug classes that target cells with low metallothionein levels.
Skills the Lab Values
PCRcell culturein vivo modelsgene suppression techniquesbioinformatics toolsmolecular pathway characterizationin vitro assayssynthetic biology techniquesdrug screening methods
Output against the department
Publications120bottom 32% of dept.271st of 402
this lab
most publishedleast published
Citations4.5kbottom 26% of dept.298th of 402
this lab
most citedleast cited
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