UTHThe University of Texas Health Science Center at Houston · Neuroscience
The EZH2 Nexus
Jun Li · Houston, Texas
Research Focus
Dr. Jun Li's lab focuses on understanding the role of a specific protein called EZH2 in diseases like Alzheimer's and Cerebral Amyloid Angiopathy. By studying the interactions between EZH2, a notable epigenetic modifier, and endothelial nitric oxide synthase (eNOS), the lab aims to uncover mechanisms of blood flow regulation, blood-brain barrier integrity, and cognitive function related to these diseases. The research uses mouse models to explore potential therapeutic strategies to mitigate cognitive decline and vascular dysfunction in dementia.
EZH2Alzheimer's DiseaseCerebral Amyloid Angiopathyblood-brain barrierendothelial nitric oxide synthasecognitive functionepigeneticsvascular dysfunction
Research Aims
3AIM 01Investigate the role of EZH2 in regulating blood flow and eNOS expression in Alzheimer's disease models.
AIM 02Examine EZH2's impact on blood-brain barrier integrity and amyloid pathology.
AIM 03Determine the effects of EZH2 inhibition on cognitive behaviors in transgenic mouse models of dementia.
Skills the Lab Values
mouse modelsepigenetic modification techniquesimmunohistochemistrybehavioral assaysquantitative PCRwestern blottinglaser scanning microscopydata analysis with Rcerebral blood flow imaging
Output against the department
Publications1,124top 2% of dept.16th of 671
this lab
most publishedleast published
Citations46ktop 8% of dept.51st of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.