University of Virginia-Main Campus · Biomedical EngineeringMesothelioma Imaging and Therapy Lab
Jiang He · Charlottesville, Virginia
Research Focus
Dr. Jiang He's lab at the University of Virginia focuses on developing new imaging and treatment methods for mesothelioma, a challenging form of cancer. The lab is working on a human monoclonal antibody that targets a specific tumor marker found in various mesothelioma subtypes. By using advanced imaging techniques, such as SPECT, and targeted alpha therapy, they aim to improve treatment outcomes for patients, especially for those suffering from difficult-to-treat forms of the disease.
mesotheliomaSPECT imagingalpha therapymonoclonal antibodiescancer treatment
Research Aims
5AIM 01Develop a targeted imaging method for mesothelioma using SPECT technology.
AIM 02Evaluate the therapeutic potential of a novel antibody for targeted alpha therapy.
AIM 03Test the efficacy and safety of the 203Pb and 212Pb isotope pair in clinical models.
AIM 04Explore the internalization properties of the selected monoclonal antibody in cancer cells.
AIM 05Determine optimal dosing schemes for effective treatment outcomes.
Skills the Lab Values
SPECT imagingantibody labelinganimal modelscell line cultureXenograft procedures
Output against the department
Publications1,322top 2% of dept.13th of 595
this lab
most publishedleast published
Citations128ktop 1% of dept.2nd of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.