Icahn School of Medicine at Mount Sinai · PharmacologyThe Cancer Cure Lab
Jian Jin · New York, New York
Research Focus
Dr. Jian Jin's lab focuses on developing new therapeutic strategies for certain types of cancers and Alzheimer's disease. They specifically research targeted treatments for MLL-rearranged leukemias, multiple myeloma, and Alzheimer's disease by inhibiting key enzymes involved in gene regulation. The lab's innovative work aims to create drug candidates that can be used in clinical trials for patients who currently have limited treatment options.
leukemiamultiple myelomaAlzheimer's diseaselysine methyltransferasetherapeutic strategiesPROTACdrug discoverycell models
Research Aims
5AIM 01Discover small-molecule degraders of WDR5 to treat MLL-rearranged leukemias.
AIM 02Develop selective inhibitors of SETD8 for treating multiple myeloma.
AIM 03Create potent inhibitors of lysine methyltransferases G9a and GLP for Alzheimer's disease.
AIM 04Evaluate the efficacy of new drugs in preclinical models of cancer and Alzheimer's disease.
AIM 05Optimize lead compounds into drug candidates for clinical use.
Skills the Lab Values
cell cultureanimal modelsdrug pharmacokineticshigh-throughput screeningmolecular dockingdrug designWestern blotRNA sequencing
Output against the department
Publications480top 11% of dept.52nd of 462
this lab
most publishedleast published
Citations22ktop 15% of dept.68th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.