Duke University · Biomedical EngineeringLab for 3D Retinal Tissue Engineering
Sharon Gerecht · Durham, North Carolina
Research Focus
Dr. Sharon Gerecht's lab at Duke University focuses on creating advanced 3D models of the inner blood-retina barrier, which is crucial for understanding retinal diseases like diabetic retinopathy. By engineering these models with human retinal cells, the lab aims to mimic the environment of healthy retinal tissue and investigate how vascular dysfunction occurs. This innovative research provides insights into the mechanisms of retinal health and disease, which could lead to better treatments.
3D tissue engineeringblood-retina barrierretinal vascular diseasesmicrophysiological modelsbiomaterials
Research Aims
3AIM 01Develop a post-capillary venule model of the healthy inner blood-retina barrier.
AIM 02Create a capillary model of the healthy inner blood-retina barrier.
AIM 03Increase the complexity of inner blood-retina barrier models to mimic extracellular environments.
Skills the Lab Values
tissue engineeringcell culturehydrogel formulationimmunofluorescenceWestern blottingstem cell techniquesmicrovessel modelingoxygen tension assessmentmatrix mechanics analysisin vitro modeling
Output against the department
Publications244top 42% of dept.242nd of 595
this lab
most publishedleast published
Citations12ktop 30% of dept.179th of 595
this lab
most citedleast cited
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