Brandeis University · BiologyThe Actin Dynamics Lab
Bruce L Goode · Waltham, Massachusetts
Research Focus
Dr. Bruce L. Goode's lab at Brandeis University focuses on understanding how the actin cytoskeleton, a crucial component of cells, is regulated and how it interacts with other structures within cells. The researchers use advanced techniques to study dynamic changes in actin in real time, which is essential for important processes like cell movement and division. By exploring how mutations in genes related to actin dynamics contribute to diseases like cancer and neurodegeneration, the lab aims to uncover insights that could lead to new therapeutic strategies.
actin cytoskeletoncell motilitygenetic manipulationmolecular dynamicscytoskeletal crosstalkdisease mechanismslive imagingprotein complexessingle molecule microscopy
Research Aims
5AIM 01Investigate how actin regulatory proteins work together to control actin dynamics.
AIM 02Explore the precise mechanisms of actin filament turnover in mammalian cells.
AIM 03Analyze the spatial and temporal regulation of formins in actin cable formation.
AIM 04Study the interactions between septins and actin-binding proteins in cell function.
AIM 05Identify proteins that link actin to diverse cellular processes.
Skills the Lab Values
single molecule TIRF microscopymolecular cloningyeast geneticslive cell imagingprotein purificationcell culture techniquesbiochemical assaysgenetic manipulation in yeast and mammalian cellscryo-electron tomography
Output against the department
Publications207top 32% of dept.326th of 1,033
this lab
most publishedleast published
Citations14ktop 26% of dept.273rd of 1,033
this lab
most citedleast cited
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