UGUniversity of Georgia · Pharmacology
Crich Lab
David Crich · Athens, Georgia
Research Focus
Dr. David Crich's lab focuses on developing next-generation aminoglycoside antibiotics that are effective against multidrug-resistant bacteria while minimizing side effects like hearing loss and kidney damage. By synthesizing and optimizing new compounds, the lab aims to create more effective treatments with improved safety profiles. Research includes a combination of laboratory assays and animal models to test efficacy and toxicity.
aminoglycoside antibioticsmultidrug resistanceototoxicitynephrotoxicitybacterial ribosomessynthetic chemistrypharmacokineticsantibiotic development
Research Aims
5AIM 01Design and synthesize new aminoglycoside antibiotic compounds.
AIM 02Optimize compounds for reduced toxicity and enhanced antibacterial activity.
AIM 03Test synthesized compounds for efficacy against multidrug-resistant bacteria.
AIM 04Evaluate the safety of new antibiotics in animal models for ototoxicity and nephrotoxicity.
AIM 05Investigate the mechanisms of resistance in bacterial strains.
Skills the Lab Values
synthesis of chemical compoundsbacterial assaysanimal modelsototoxicity testingnephrotoxicity testingcell culturemolecular biology techniquespharmacokinetic analysisdrug formulation
Output against the department
Publications702top 5% of dept.22nd of 462
this lab
most publishedleast published
Citations21ktop 17% of dept.77th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.