University of California-Irvine · Microbiology & ImmunologyJames Lab
Anthony A. James · Irvine, California
Research Focus
Dr. Anthony A. James' lab at UC Irvine focuses on developing innovative genetic strategies to combat malaria, a disease that significantly impacts global health. They are particularly interested in using gene-drive systems, which harness CRISPR technology, to alter the reproductive capabilities of malaria-carrying mosquitoes, thereby reducing their populations and spreading resistance to the malaria parasite. The lab's work aims to provide new tools that are effective, safe for humans and the environment, and resilient against reinvasion by susceptible mosquito populations.
malariagene driveCRISPRvector controlmosquitoes
Research Aims
3AIM 01Develop gene-drive systems to modify mosquito vector populations for malaria control.
AIM 02Evaluate the impact of these systems on the reproductive success of malaria-carrying mosquitoes.
AIM 03Assess the stability of gene-drive systems across multiple generations of mosquitoes.
Skills the Lab Values
CRISPR/Cas technologygenetic engineeringDNA analysispopulation biologymolecular genetics
Output against the department
Publications702top 3% of dept.15th of 486
this lab
most publishedleast published
Citations34ktop 9% of dept.42nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.