University of Maryland, Baltimore · PharmacologyBloch Muscle Lab
Robert J Bloch · Baltimore, Maryland
Research Focus
Dr. Robert J. Bloch's lab at the University of Maryland focuses on finding new therapies for muscle diseases caused by the absence of the protein dysferlin. The lab studies how mutations in the dysferlin gene lead to conditions like Limb Girdle Muscular Dystrophy and Miyoshi Myopathy, impacting muscle repair and calcium signaling. They aim to develop protein-based treatments that help restore these functions and test their effectiveness in preclinical models.
muscular dystrophydysferlinCa2+ signalingC2 domaingene therapymuscle repairprotein engineeringchimeric construct
Research Aims
4AIM 01Optimize engineered constructs of Dysf-C2A for muscle repair
AIM 02Identify how effective chimeric constructs target to triad junctions
AIM 03Determine if Ca2+ binding at junctions accounts for the constructs' activities
AIM 04Test AAV encoding constructs in dysferlinopathic mice for therapeutic effects
Skills the Lab Values
cell cultureprotein purificationexperimental designmolecular cloningin vitro assaysanimal modelswestern blottingfluorescent microscopy
Output against the department
Publications428top 13% of dept.62nd of 462
this lab
most publishedleast published
Citations11ktop 36% of dept.168th of 462
this lab
most citedleast cited
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