University of Nebraska Medical Center · PharmacologyImmunology and Viral Interactions Lab
Siddappa N Byrareddy · Omaha, Nebraska
Research Focus
Dr. Siddappa N Byrareddy's lab at the University of Nebraska Medical Center focuses on understanding how substances like cocaine and cannabinoids influence the immune response and disease progression in HIV and related infections. They study the gut-brain connection and how factors like sex differences affect viral reservoirs and inflammation in the brain and intestines. The goal is to find better therapies for managing HIV/SIV and other chronic inflammatory conditions.
HIVcannabiscocaineinflammasomegut-brain axisopioidssex differencesneuroinflammationviral reservoirs
Research Aims
5AIM 01Investigate epigenetic mechanisms of cannabinoid-mediated reduction of cocaine-induced inflammasome activation
AIM 02Determine the impact of THC and cART on dysregulation of the microbiota-gut-brain axis
AIM 03Identify molecular mechanisms of THC's counteraction on cocaine-induced DNA hypomethylation and inflammasome activation
AIM 04Explore sex differences in seeding and maintaining HIV/SIV reservoirs in opiate-dependent individuals
AIM 05Document the location and persistence of viral reservoirs influenced by sex and substance use.
Skills the Lab Values
cell culturePCRWestern blotflow cytometryRNA sequencingmouse modelsin vitro assaysimmunofluorescenceepigenetic analysisdata modeling
Output against the department
Publications216top 39% of dept.180th of 462
this lab
most publishedleast published
Citations11ktop 34% of dept.158th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.