Stony Brook University · BiologyIntracerebral Hemorrhage Research Lab
Ke Jian Liu · Stony Brook, New York
Research Focus
Dr. Ke Jian Liu's lab at Stony Brook University focuses on understanding how intracerebral hemorrhage (ICH) causes brain damage, specifically through a compound called zinc protoporphyrin (ZnPP). Their research investigates the relationship between tissue hypoxia, oxidative stress, and ZnPP formation in the brain after hemorrhage. The lab aims to explore whether repurposing certain FDA-approved drugs can provide new therapeutic options to reduce brain injury caused by ICH.
intracerebral hemorrhagezinc protoporphyrinbrain damagehypoxiatherapeutic interventionoxidative stressFDA-approved drugsneuroprotectionferrochelatase
Research Aims
3AIM 01Determine conditions for ZnPP generation and its contribution to brain damage following ICH.
AIM 02Investigate the neurotoxicity of ZnPP under hypoxic conditions and the potential benefits of oxygen treatment.
AIM 03Evaluate the role of protein kinase inhibitors in reducing ZnPP levels and alleviating brain damage in ICH.
Skills the Lab Values
cell culturein vivo modelsWestern blotflow cytometryquantitative PCRdrug repurposinganimal surgeryoxidative stress assaysbiochemical assays
Output against the department
Publications214top 30% of dept.307th of 1,033
this lab
most publishedleast published
Citations9.6ktop 39% of dept.406th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.