Duke University · BiologyMacias Oncology Lab
Everardo Macias · Durham, North Carolina
Research Focus
Dr. Everardo Macias's lab at Duke University focuses on understanding and combating neuroendocrine prostate cancer, a severe form of prostate cancer that often emerges in patients who have become resistant to standard treatments. His research aims to explore a specific target, a protein known as TTK, which is crucial in cell division and is overexpressed in this type of cancer. Through a combination of lab studies and animal models, the team investigates how targeting TTK can slow cancer growth and improve treatment outcomes for patients.
neuroendocrine prostate cancerTTKphospho-proteomicscancer therapypreclinical modelsbiomarker identificationcell line studiesgene targetingtreatment resistance
Research Aims
3AIM 01Identify the role of RABL6 as a phospho-target in NEPC cells.
AIM 02Test the therapeutic effects of TTK targeting in patient-derived xenograft models.
AIM 03Evaluate the efficacy of combining TTK inhibitors with standard chemotherapy for NEPC.
Skills the Lab Values
cell cultureanimal models (xenografts)phospho-proteomicsdrug efficacy testinggenetic manipulationclinical grade inhibitor testingtumor immune profilingRNA sequencingdata analysis in cancer research
Output against the department
Publications30bottom 4% of dept.990th of 1,033
this lab
most publishedleast published
Citations676bottom 3% of dept.1,003rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.