University of North Carolina at Chapel Hill · PhysiologyThe UBE3A Movement Lab
Adam Hantman · Chapel Hill, North Carolina
Research Focus
Dr. Adam Hantman's lab at UNC Chapel Hill focuses on understanding how changes in a specific gene called UBE3A affect movement control in disorders like Angelman syndrome and Dup15q syndrome. The lab uses mouse models to explore how UBE3A misexpression alters brain circuit dynamics and motor skills. Ultimately, the research aims to develop new gene therapy approaches to improve motor function in affected individuals.
UBE3AAngelman syndromeDup15q syndromemouse modelsmotor control
Research Aims
3AIM 01Investigate the impact of Ube3a copy number on skilled movements.
AIM 02Analyze how Ube3a copy number affects neuronal dynamics in the brain.
AIM 03Evaluate how restoring UBE3A expression in specific circuits impacts motor function.
Skills the Lab Values
gene therapy techniquesmouse behavioral assaysneural circuit mappingelectrophysiologyPCR
Output against the department
Publications62bottom 11% of dept.254th of 286
this lab
most publishedleast published
Citations6.5ktop 50% of dept.144th of 286
this lab
most citedleast cited
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