University of Pittsburgh-Pittsburgh Campus · PharmacologyCardiovascular Redox Lab
Adam Carl Straub · Pittsburgh, Pennsylvania
Research Focus
Dr. Adam Carl Straub's research lab focuses on understanding how certain proteins in the body, specifically cytochrome b5 reductase 3, affect the cardiovascular system, especially during conditions like ischemic stroke. By investigating genetic variations and their impact on redox signaling, particularly in African American populations, the lab aims to develop better treatments for stroke and cardiovascular diseases. Students in this lab will learn about the underlying biological mechanisms of these conditions and how to translate this knowledge into potential new therapies.
ischemic strokeredox regulationcytochrome b5 reductase 3oxidative stresscardiovascular disease
Research Aims
3AIM 01Investigate how the CYB5R3 T117S variant affects cerebrovascular function in stroke models.
AIM 02Determine the role of nitric oxide signaling in cerebral vascular damage for different CYB5R3 variants.
AIM 03Explore potential therapies to mitigate stroke damage using sGC activators and stimulators.
Skills the Lab Values
mouse modelsgenetic engineeringWestern blotPCRcell cultureflow cytometrydata analysisbiochemical assays
Output against the department
Publications243top 34% of dept.157th of 462
this lab
most publishedleast published
Citations6.2kbottom 44% of dept.259th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.