Vanderbilt University · BiologyThe Molecular Pathways Lab
Jeffrey M Spraggins · Nashville, Tennessee
Research Focus
Dr. Jeffrey M. Spraggins' lab at Vanderbilt University focuses on understanding the molecular basis of kidney diseases and Alzheimer's disease through advanced imaging techniques. By utilizing cutting-edge multimodal imaging and spatially resolved molecular technologies, the lab aims to identify key pathways in these diseases, helping to uncover potential biomarkers and therapeutic targets. The research combines expertise in nephrology, analytical chemistry, and cell biology, making it a hub for innovative biomedical discovery.
multimodal imagingmass spectrometryspatial omicsAlzheimer's diseasekidney diseaseproteomicstranscriptomicsdisease biomarkersagingbiomolecular imaging
Research Aims
5AIM 01Generate high-resolution images of kidney biopsies to understand disease heterogeneity.
AIM 02Develop molecular atlases of Alzheimer's disease tissue to reveal neuropathological complexities.
AIM 03Identify biomarkers of acute kidney injury and chronic kidney disease.
AIM 04Analyze cell-type specific molecular changes between normal aging and Alzheimer's disease.
AIM 05Utilize advanced data strategies to interpret multiomic data for therapeutic insights.
Skills the Lab Values
mass spectrometryimaging mass spectrometrylaser capture microdissectionspatial transcriptomicsspatial proteomicsdata analysismicroscopybioinformaticsnetwork analysismolecular profiling
Output against the department
Publications281top 21% of dept.215th of 1,033
this lab
most publishedleast published
Citations6.9kbottom 48% of dept.539th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.