University of Kentucky · BiologySelenica Lab
Maj-Linda B Selenica · Lexington, Kentucky
Research Focus
Dr. Selenica's lab focuses on understanding the role of a specific protein modification in brain diseases like Alzheimers and related dementias. They investigate how this modification affects a protein called TDP-43, which is linked to cognitive decline. The research aims to uncover how changes in TDP-43 contribute to neurological disorders, providing insights that could lead to new therapeutic approaches.
TDP-43citrullinationAlzheimer's diseaseneuropathologymouse modelsneurobehavioral deficitsprotein dynamicspost-translational modificationsynaptic dysfunction
Research Aims
3AIM 01Investigate how genetic changes in PAD4 affect TDP-43 behavior in neurons.
AIM 02Assess the impact of specific protein modifications on TDP-43 dynamics in primary neurons.
AIM 03Examine regional vulnerability of the human brain to TDP-43 pathology in relevant disease models.
Skills the Lab Values
cell culturemouse modelsWestern blotRNA extractionimmunohistochemistrygenetic manipulationbehavioral assaysmicroscopyprotein assays
Output against the department
Publications10bottom 1% of dept.1,019th of 1,033
this lab
most publishedleast published
Citations11ktop 32% of dept.334th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.