Virginia Commonwealth University · GeneticsFisher Lab
Paul B Fisher · Richmond, Virginia
Research Focus
Paul B Fisher's lab focuses on developing new treatments for metastatic triple negative breast cancer (TNBC). They are studying a gene called MDA-9 that plays a key role in cancer spread and testing a new drug, PDZ1i, which may help prevent tumor growth and improve responses to existing therapies. This innovative research could lead to better cancer treatments and clinical trials, ultimately benefiting patients with advanced breast cancer.
breast cancermetastasistriple negative breast cancerMDA-9drug developmentsmall molecule inhibitorsclinical trialsTumor growth controlPDZ1ichemotherapy
Research Aims
5AIM 01Develop and test the small molecule inhibitor PDZ1i for clinical applications
AIM 02Identify how PDZ1i influences immune responses to tumors
AIM 03Determine the gene targets and pathways regulated by MDA-9 in cancer cells
AIM 04Explore the effects of PDZ1i combined with chemotherapy in tumor models
AIM 05Evaluate the potential of PDZ1i to progress into phase I clinical trials.
Skills the Lab Values
cell culturemouse modelsnanotechnologygene expression analysispharmacokineticsdrug formulationimmunohistochemistrybioinformaticsepigenetic analysisclinical trial design
Output against the department
Publications1,137top 3% of dept.8th of 259
this lab
most publishedleast published
Citations52ktop 12% of dept.30th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.