University of Louisville · PharmacologyThe Chromium Dynamics Lab
John Pierce Wise · Louisville, Kentucky
Research Focus
Dr. John Pierce Wise's lab at the University of Louisville focuses on understanding how certain metals, particularly hexavalent chromium, contribute to the development of lung cancer through a process called chromosomal instability. The lab investigates the biological mechanisms by which these metals induce cancerous changes in lung cells, employing a range of models including human cell lines, 3D cultures, and animal studies. The ultimate goal is to uncover new strategies for prevention and treatment of lung cancer, addressing a critical public health issue related to environmental exposures.
lung cancerchromosomal instabilitymetal carcinogenesishexavalent chromiumcancer mechanismsenvironmental health3D cell cultureneoplastic transformationpublic health
Research Aims
5AIM 01Investigate how metals induce chromosomal instability in lung cells.
AIM 02Define key mechanisms of metal-induced carcinogenesis.
AIM 03Translate findings from model systems to human populations.
AIM 04Explore heritable aspects of cellular changes caused by metal exposure.
AIM 05Develop new strategies for lung cancer risk assessment and prevention.
Skills the Lab Values
cell culture3D cell culturemouse modelschromosomal analysisWestern blotRNA sequencinginduced pluripotent stem cellsanimal studiesenvironmental health assessments
Output against the department
Publications328top 23% of dept.107th of 462
this lab
most publishedleast published
Citations8.2ktop 46% of dept.211th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.