University of Pittsburgh-Pittsburgh Campus · Microbiology & ImmunologyTuberculosis Vaccine Research Lab
Joanne L. Flynn · Pittsburgh, Pennsylvania
Research Focus
Dr. Joanne L. Flynn's lab focuses on improving the efficacy of vaccines against tuberculosis (TB), a major global health concern. The lab investigates new strategies to enhance the immune response to the BCG vaccine using modern techniques and animal models. Their research aims to better understand how to protect against TB and identify key markers of vaccine effectiveness.
tuberculosisBCG vaccineimmune responseCD8 T cellsmachine learningvaccination strategynon-human primatevaccine efficacyimmunology
Research Aims
4AIM 01Evaluate the immunogenicity of an enhanced BCG vaccine regimen in an animal model.
AIM 02Compare the ability of the new vaccine regimen to prevent TB infection and reduce bacterial burden.
AIM 03Examine immune responses in lungs and lymph nodes after vaccination and infection.
AIM 04Identify immune parameters that correlate with protection against TB using machine learning techniques.
Skills the Lab Values
animal modelsflow cytometryimmunologic profilingPET CT imagingbioinformaticscell culturemachine learningtranscriptional analysisaerosol delivery
Output against the department
Publications337top 13% of dept.65th of 486
this lab
most publishedleast published
Citations34ktop 9% of dept.43rd of 486
this lab
most citedleast cited
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