University of Pennsylvania · PhysiologyLakadamyali Cell Lab
Melike Lakadamyali · Philadelphia, Pennsylvania
Research Focus
Melike Lakadamyali's lab at the University of Pennsylvania explores how cells organize themselves at a microscopic level and how these structures are critical for cell function. By using cutting-edge imaging technologies, the lab studies how organelles and proteins are spatially arranged and how this organization influences health and disease. Their research aims to uncover the links between cellular organization, gene activity, and the overall functionality of cells.
super-resolution microscopycell organizationorganelle functiongene activitybiochemical reactionscellular homeostasischromatin structuremolecular assembliestransport mechanismsdisease pathology
Research Aims
3AIM 01Investigate how motor proteins and their assemblies facilitate organelle transport and positioning.
AIM 02Determine the relationship between organelle identity, positioning, and function in health and disease.
AIM 03Examine how chromatin structure influences gene activity and cellular identity.
Skills the Lab Values
super-resolution microscopycell cultureprotein imagingimmunofluorescencelive cell imagingmicroscopy techniquesdata analysis in imagingquantitative microscopymolecular biology techniquesbiochemical assays
Output against the department
Publications184top 37% of dept.105th of 286
this lab
most publishedleast published
Citations11ktop 29% of dept.84th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.