University of Pennsylvania · BiologyJordan-Sciutto Myelination Lab
Kelly L Jordan-Sciutto · Philadelphia, Pennsylvania
Research Focus
Dr. Kelly L Jordan-Sciutto's lab at the University of Pennsylvania focuses on understanding how HIV infection and antiretroviral therapy (ART) impact brain health, particularly looking at oligodendrocytes, which are crucial for creating myelin. They study how these factors disrupt the development of myelin, potentially leading to cognitive disorders in people living with HIV. The lab also investigates the effects of cannabinoids on inflammation and neuroprotection in the context of HIV and ART treatments.
HIVneurocognitive disordersoligodendrocytesantiretroviral therapycannabinoidsinflammationmyelinstress responselipid metabolismcentral nervous system
Research Aims
3AIM 01Investigate the formation of stress granules in oligodendrocytes following HIV infection and ART treatment.
AIM 02Assess how HIV and ART alter lipid composition and regulatory mechanisms in oligodendrocytes.
AIM 03Explore the impact of cannabinoids on HIV-induced inflammation and neuronal dysfunction in a tri-culture model of CNS cells.
Skills the Lab Values
cell cultureRNA sequencingin vitro modelsanimal modelsimmunofluorescencereal-time PCRstress granule analysiscytokine profilingmicroglial activation assessmentgenetic analysis
Output against the department
Publications113bottom 40% of dept.620th of 1,033
this lab
most publishedleast published
Citations4.2kbottom 32% of dept.702nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.