University of Notre Dame · ChemistryMobashery Antibiotic Lab
Shahriar Mobashery · Notre Dame, Indiana
Research Focus
Dr. Shahriar Mobashery's lab at the University of Notre Dame focuses on understanding how the bacterium Staphylococcus aureus becomes resistant to beta-lactam antibiotics, which are crucial for treating infections. The research aims to identify novel agents that could reverse this resistance and restore the efficacy of these antibiotics. The lab employs various techniques to study the genetic and molecular mechanisms involved in this antibiotic resistance.
beta-lactam resistanceStaphylococcus aureusantibiotic resistanceBlaR proteinb-lactamasephosphorylationmembrane proteins
Research Aims
5AIM 01Investigate the mechanisms underlying beta-lactam resistance in Staphylococcus aureus.
AIM 02Identify agents that can inhibit the BlaR protein to reverse antibiotic resistance.
AIM 03Characterize the membrane anchoring of BlaZ and its phosphorylation dependencies.
AIM 04Explore the generality of phosphorylation-dependent membrane protein sequestration in S. aureus.
AIM 05Develop a discovery funnel for new compounds to combat antibiotic resistance.
Skills the Lab Values
fluorescent imagingprotein purificationX-ray crystallographykinetic assaysmolecular cloningbacterial cell culturebiochemical assaysstructure-activity relationship analysisphosphorylation site identification
Output against the department
Publications611top 12% of dept.25th of 216
this lab
most publishedleast published
Citations26ktop 17% of dept.37th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.