Johns Hopkins University · NeuroscienceMiller Neuroimaging Lab
Michael I Miller · Baltimore, Maryland
Research Focus
Dr. Michael I. Miller leads a research lab at Johns Hopkins University focused on understanding how Alzheimer's disease affects specific brain regions, particularly the entorhinal cortex, which deteriorates early in the disease. The lab employs advanced MRI techniques along with histological and molecular analyses to correlate structural brain changes with cognitive impairment and disease progression. This research aims to develop new MRI-based biomarkers that could aid in the early detection and treatment of Alzheimer's disease.
Alzheimer's DiseaseMRINeurofibrillary TanglesHistologyGene ExpressionCognitive ImpairmentBrain AtrophyMolecular ProfilingSpatial Transcriptomics
Research Aims
4AIM 01Establish a protocol for integrating high-field MRI with histological analyses of the entorhinal cortex.
AIM 02Identify spatial gene expression signatures in entorhinal cortex neurons related to Alzheimer's disease.
AIM 03Correlate MRI-derived structural changes with pathological and molecular data to understand Alzheimer's disease progression.
AIM 04Develop MRI-based biomarkers of tau pathology for potential clinical application.
Skills the Lab Values
MRI imaging techniquesHistological analysisTissue processingGene expression analysisSpatial transcriptomicsPostmortem brain studiesData integration across modalitiesCognitive assessment methodsStatistical software (e.g., R or Python)
Output against the department
Publications590top 9% of dept.60th of 671
this lab
most publishedleast published
Citations38ktop 9% of dept.60th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.