Harvard University · Microbiology & ImmunologyKasper Lab
Dennis L. Kasper · Cambridge, Massachusetts
Research Focus
Dr. Dennis L. Kasper's lab at Harvard Medical School investigates how the gut's immune system, particularly a part called the complement system, protects against infections. They focus on how this system works locally in the gut rather than relying just on the blood. Recent findings show that a protein called C3, produced in the gut, plays a crucial role in fighting off pathogens such as bacteria that cause diarrhea. The lab aims to understand how the gut microbiome influences C3 levels and explore new therapeutic strategies for combating infectious diseases.
gut microbiomecomplement systemintestinal immunityinfectious diarrheapathogen resistance
Research Aims
3AIM 01Determine the key cellular source of C3 in the gut that combats infection.
AIM 02Identify proteins and pathways activating the gut complement system.
AIM 03Develop synthetic molecules to induce C3 with low inflammation.
Skills the Lab Values
gnotobiotic mouse modelsmicrobiota analysissingle-cell RNA sequencingmicroscopyprotein pathway identification
Output against the department
Publications359top 11% of dept.54th of 486
this lab
most publishedleast published
Citations44ktop 5% of dept.25th of 486
this lab
most citedleast cited
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