Icahn School of Medicine at Mount Sinai · GeneticsHeme Harmony Lab
Makiko Yasuda · New York, New York
Research Focus
Dr. Makiko Yasuda's lab at the Icahn School of Medicine focuses on understanding how the liver maintains proper levels of heme, an important molecule for various biological processes. Their research explores how liver cells and macrophages work together to manage heme levels, which is crucial for health. This work could lead to better treatments for diseases related to heme imbalances, particularly conditions affecting the liver.
heme homeostasisliver functionmacrophageshepatocytesacute hepatic porphyriascellular traffickingsingle-cell RNA sequencinganimal modelsco-culture systemsgene expression
Research Aims
3AIM 01Identify the cell types involved in heme transfer from macrophages to hepatocytes.
AIM 02Investigate the mechanisms behind hepatocyte heme acquisition activation in vivo.
AIM 03Explore candidate genes and pathways related to hepatocyte heme acquisition using single-cell RNA sequencing.
Skills the Lab Values
cell cultureprimary cell co-culture techniquessingle-cell RNA sequencingmouse modelsin vivo experimentationRNA interferenceproteomicsbiochemical assayssignal transduction analysisgene expression analysis
Output against the department
Publications49bottom 9% of dept.234th of 259
this lab
most publishedleast published
Citations2.9kbottom 16% of dept.217th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.