The University of Texas Health Science Center at San Antonio · BiochemistryAPOBEC Enzyme and Cancer Dynamics Lab
Reuben S Harris · San Antonio, Texas
Research Focus
Dr. Reuben S. Harris leads a research lab focused on understanding APOBEC enzymes and their role in cancer mutations. His team studies how these enzymes contribute to genetic changes in various cancer types, such as bladder and breast cancer, which can lead to treatment resistance and metastasis. The lab aims to develop new therapies that inhibit these enzymes, ultimately improving cancer treatment outcomes.
APOBEC enzymescancer mutagenesisdrug resistancemutation preventioncancer therapy
Research Aims
3AIM 01Investigate the mechanisms of APOBEC-mediated mutagenesis in cancer cells.
AIM 02Develop small molecule inhibitors targeting APOBEC enzymes.
AIM 03Understand the impact of APOBEC mutations on cancer evolution and treatment response.
Skills the Lab Values
cell culturemolecular cloningbiochemical assaysprotein purificationanimal modelsspectroscopychemical synthesisbioinformaticsstructural biology
Output against the department
Publications483top 9% of dept.36th of 402
this lab
most publishedleast published
Citations25ktop 15% of dept.60th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.