University of Minnesota-Twin Cities · Microbiology & ImmunologyMasopust Lab
David Masopust · Minneapolis, Minnesota
Research Focus
Dr. David Masopust's lab at the University of Minnesota focuses on understanding how certain T cells, called resident memory T cells, contribute to both immunity and disease. The lab explores how these cells function in response to infections, their longevity, and their potential roles in autoimmunity and cancer therapy. Through innovative mouse models and experimental techniques, the research aims to develop new strategies for vaccines and immune therapies that can effectively combat various diseases.
T cell immunityresident memory T cellsautoimmunityagingcancer therapyimmunotherapyT cell memoryimmune responseschronic disease
Research Aims
5AIM 01Investigate how resident memory T cells develop and function in tissues.
AIM 02Identify mechanisms that allow T cells to retain functional longevity across multiple lifespans.
AIM 03Explore the impact of aging on T cell memory and immune responses.
AIM 04Develop new assays to evaluate T cell behavior in mouse and human models.
AIM 05Understand how to manipulate T cell responses for improved vaccination and therapy outcomes.
Skills the Lab Values
mouse modelscell cultureflow cytometryCRISPRimmunohistochemistrygene editingtranscriptional profilingmetabolic analysisdata analysis with R or Python
Output against the department
Publications237top 25% of dept.122nd of 486
this lab
most publishedleast published
Citations31ktop 10% of dept.47th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.