UTHThe University of Texas Health Science Center at Houston · Biology
Pochynyuk Lab
Oleh Pochynyuk · Houston, Texas
Research Focus
Oleh Pochynyuk's lab at the University of Texas Health Science Center focuses on understanding how the kidneys regulate sodium levels and blood pressure, especially in the context of hypertension. They study a specific signaling pathway involving proteins called Epac1 and Epac2, which play important roles in sodium transport within the kidneys. By exploring how to effectively target these proteins with new drugs, the lab aims to develop better treatments for hypertension, a major health issue.
renal physiologysodium transporthypertensionEpac signalingdrug discovery
Research Aims
3AIM 01Assess the impact of Epac signaling on sodium handling in the kidneys using mouse models.
AIM 02Investigate the molecular mechanisms behind Epac's regulation of sodium transport.
AIM 03Develop and test new pharmacological inhibitors of Epac isoforms to treat hypertension.
Skills the Lab Values
animal modelsRNA sequencingdrug developmentmolecular biology techniqueselectrophysiology
Output against the department
Publications179top 37% of dept.381st of 1,033
this lab
most publishedleast published
Citations4.0kbottom 30% of dept.720th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.