Rutgers University-New Brunswick · BiologySadoshima Cardiac Lab
Junichi Sadoshima · New Brunswick, New Jersey
Research Focus
Dr. Junichi Sadoshima's lab at Rutgers focuses on understanding the cellular processes that contribute to heart aging and failure. The research emphasizes how aging affects heart cells, particularly through mechanisms like cellular senescence and oxidative stress, leading to heart disease. By studying the roles of autophagy and cysteine oxidation in cardiac cells, the lab aims to uncover potential strategies to improve heart health and longevity.
cardiac agingcellular senescencecysteine oxidationautophagymitochondrial functionheart diseaseheart failurecardiomyocytesoxidative stress
Research Aims
5AIM 01Investigate the role of autophagy in cardiac senescence and its effects on heart function.
AIM 02Examine how cysteine oxidation influences the function of critical heart proteins during stress.
AIM 03Explore alternative mitophagy pathways in the context of aging cardiomyocytes.
AIM 04Develop interventions to counteract cardiac dysfunction related to aging and oxidative stress.
AIM 05Analyze the molecular mechanisms behind heart cell survival and cell death during heart failure.
Skills the Lab Values
cell culturemouse modelsgenetic manipulationproteomicsWestern blotqPCRimmunohistochemistryflow cytometryAAV-mediated gene delivery
Output against the department
Publications694top 3% of dept.36th of 1,033
this lab
most publishedleast published
Citations64ktop 3% of dept.27th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.