UWMUniversity of Wisconsin-Madison · Neuroscience
Paulsen Lab
Jane S Paulsen · Madison, Wisconsin
Research Focus
Dr. Jane S. Paulsen's lab focuses on understanding and improving the diagnosis of a genetic condition called CADASIL, which affects blood flow to the brain and can lead to dementia. The lab investigates how changes in the retina can provide insights into the progression of CADASIL and potentially other forms of vascular dementia. By using advanced imaging techniques, they aim to identify reliable biomarkers that can help in earlier diagnosis and treatment effectiveness in clinical trials.
CADASILvascular dementiaretinal imagingbiomarkersneurology
Research Aims
4AIM 01Enroll 180 participants with CADASIL to study their retinal health.
AIM 02Investigate retinal imaging measures as biomarkers for CADASIL progression.
AIM 03Analyze the relationship between retinal changes and cognitive impairment in CADASIL patients.
AIM 04Develop potential diagnostic tools for clinical trials related to neurodegenerative diseases.
Skills the Lab Values
optical coherence tomography (OCT)OCT-angiographyspectral domain OCT (SD-OCT)data collectionclinical trial design
Output against the department
Publications493top 11% of dept.77th of 671
this lab
most publishedleast published
Citations31ktop 12% of dept.83rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.