Harvard University · BiochemistryThe Integrator Insight Lab
Karen L Adelman · Cambridge, Massachusetts
Research Focus
Dr. Karen L. Adelman's lab at Harvard Medical School focuses on understanding how the Integrator complex regulates gene expression in response to various signals. This work is crucial for deciphering mechanisms underlying normal development and diseases that arise from dysfunctions in these processes, such as cancer and developmental disorders. The research provides insights into how cells respond to stress and environmental cues by controlling the production of messenger RNA.
Integrator complexgene expressionRNA polymerase IIgene regulationtranscription
Research Aims
3AIM 01Investigate the roles of the Integrator complex's endonuclease and phosphatase activities in gene regulation.
AIM 02Determine how cellular stress signals activate normally attenuated genes.
AIM 03Explore the role of the Z3 complex in the function of the Integrator complex.
Skills the Lab Values
cell culturegene cloningRNA extractionChIP-seqprotein purificationWestern blotqPCRbioinformaticsmodel organism studiesmass spectrometry
Output against the department
Publications190top 45% of dept.180th of 402
this lab
most publishedleast published
Citations13ktop 37% of dept.150th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.