University of Colorado Boulder · ChemistryAntimicrobial Resistance and Biochemical Characterization Lab
Marcelo C. Sousa · Boulder, Colorado
Research Focus
Dr. Marcelo C. Sousa's lab at the University of Colorado studies how certain bacteria, specifically Gram-negative ones, develop resistance to important antibiotics like colistin. By exploring the modifications in a component called Lipid A, which bacteria alter to evade these drugs, the lab seeks to identify new ways to make resistant pathogens susceptible again. This research is crucial for improving treatment options for serious infections caused by multidrug-resistant bacteria.
antimicrobial resistanceLipid A modificationcolistinGram-negative bacteriainnate immune systemdrug developmentpathogen resistancebiochemical characterization
Research Aims
5AIM 01Investigate the mechanisms of Lipid A modification in Gram-negative bacteria.
AIM 02Characterize proteins involved in colistin resistance for potential drug targeting.
AIM 03Develop inhibitors that can reverse antibiotic resistance mechanisms.
AIM 04Implement assays to quantitatively assess the activity of inhibitors in bacteria.
AIM 05Create a platform for testing treatments against multidrug-resistant pathogens.
Skills the Lab Values
cell culture techniquesbiochemical assaysprotein characterizationmolecular modelingdrug screening methodsgenetic mutation analysiscryoelectron microscopydata analysisantibiotic susceptibility testing
Output against the department
Publications79bottom 15% of dept.181st of 216
this lab
most publishedleast published
Citations3.3kbottom 21% of dept.170th of 216
this lab
most citedleast cited
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