University of California-Davis · PharmacologyGoldman Lab
Yale E Goldman · Davis, California
Research Focus
Yale E. Goldman's lab at UC Davis focuses on understanding how molecular motors and ribosomes function in cells. They study the dynamics of these cellular machines, which are crucial for protein synthesis and transport within cells, using cutting-edge biophysical techniques. Their research aims to uncover mechanisms that contribute to diseases like muscular dystrophy and cystic fibrosis, with the goal of identifying potential therapeutic strategies.
molecular motorsribosomeprotein synthesismechanobiologysingle-molecule biophysicsmuscular dystrophycystic fibrosisgene expressioncellular transportmechanical force
Research Aims
5AIM 01Investigate the structural dynamics of ribosomes during protein synthesis.
AIM 02Study the unique properties of various myosin isoforms.
AIM 03Develop intracellular force sensors to explore mechanobiological signaling.
AIM 04Compare eukaryotic and bacterial protein synthesis mechanisms.
AIM 05Examine drug interactions that enhance read-through of premature termination codons.
Skills the Lab Values
single-molecule fluorescenceoptical trappingbiophysical techniquesFRETprotein biochemistrycell culturegenomic analysismicroscopydata analysismechanical property assessment
Output against the department
Publications313top 26% of dept.117th of 462
this lab
most publishedleast published
Citations16ktop 25% of dept.114th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.