Harvard University · BiologyCytokine Dynamics and Immunity Lab
Jennifer E Oyler-Yaniv · Cambridge, Massachusetts
Research Focus
Dr. Jennifer Oyler-Yaniv's lab at Harvard Medical School studies how immune signals, specifically cytokines produced by T-cells, spread through tissues and influence immune responses. By exploring the limited range of these signals, the lab aims to understand how local differences in cytokine availability can lead to variations in gene expression and immune cell behavior. This research is important for developing better strategies for immunotherapy and other treatments that rely on understanding immune dynamics in complex environments.
cytokinesT-cell signalingimmune responsegene expression variabilitytissue immunology
Research Aims
3AIM 01Characterize the spatial extent of T cell-derived cytokines using in vitro assays and imaging techniques.
AIM 02Explore the dynamics of IL-2 signaling niche formation and maintenance in 3D cultures and mouse models.
AIM 03Link gene expression variability to cytokine spatial heterogeneity through probabilistic modeling.
Skills the Lab Values
3D cell culturelive-cell microscopycytokine penetration assayssingle-cell transcriptomicsbiostatistical modeling