Boston University · PharmacologyTemporal Lobe Epilepsy Research Center
Shelley J Russek · Boston, Massachusetts
Research Focus
Dr. Shelley J Russek's lab studies how specific signaling pathways in the brain contribute to epilepsy, particularly temporal lobe epilepsy (TLE). By examining excitatory neurons in mouse models, they aim to understand how these pathways affect brain inflammation and neuronal function, which could lead to new treatments for TLE. Their research combines various techniques to explore the interactions between genes, brain cells, and potential therapies.
temporal lobe epilepsySTAT3neural circuit remodelinginflammationneuropharmacologysynaptic plasticitytranscriptomicsmouse modelsgene expression
Research Aims
5AIM 01Investigate how STAT3 signaling in excitatory neurons influences epilepsy progression.
AIM 02Identify gene expression changes in response to kainic acid-induced seizures.
AIM 03Explore the relationship between excitatory neuron STAT3 signaling and glial activation.
AIM 04Determine the effects of selective STAT3 knockout on inflammatory responses.
AIM 05Develop targeted therapies based on the understanding of JAK/STAT pathways.
Skills the Lab Values
RNA sequencingtissue culturemouse modelselectrophysiologybehavioral assaysgenetic engineeringtransgenic techniquesmolecular imagingdata analysis with Python
Output against the department
Publications77bottom 17% of dept.383rd of 462
this lab
most publishedleast published
Citations3.8kbottom 29% of dept.329th of 462
this lab
most citedleast cited
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