University of Alabama at Birmingham · BiochemistryCingolani Lab
Gino Cingolani · Birmingham, Alabama
Research Focus
Dr. Gino Cingolani's lab at the University of Alabama at Birmingham focuses on understanding how specific signaling proteins called STAT1 and STAT3 function in the body, especially in relation to innate immunity and in disease states. The lab also investigates how viruses deliver their genetic material into cells, exploring both bacterial viruses and herpesviruses. Research in this lab combines cutting-edge techniques to visualize and analyze these complex biological processes, potentially leading to new therapies for infectious diseases and immune disorders.
STAT1STAT3viral genome deliveryimmunitybiophysicsstructural biologytransport mechanismscryogenic electron microscopycell signalingmolecular machines
Research Aims
5AIM 01Investigate the mechanisms by which STAT1 and STAT3 are transported into the cell nucleus during immune responses.
AIM 02Catalog the gain-of-function mutations in STAT1 and STAT3 and their impact on signaling.
AIM 03Explore how bacteriophages deliver their genomes through bacterial membranes.
AIM 04Understand the mechanisms by which herpesviruses insert their genetic material into human cells.
AIM 05Integrate knowledge of transport mechanisms to develop novel therapeutic strategies.
Skills the Lab Values
cryogenic electron microscopyprotein purificationcell culturebiochemical assaysX-ray crystallographyNuclear Pore Complex analysismutagenesisgenomic sequencingflow cytometryimmunoblotting
Output against the department
Publications195top 44% of dept.175th of 402
this lab
most publishedleast published
Citations7.5kbottom 41% of dept.237th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.