Northeastern University · EngineeringThe Protein Pathways Lab
Nikolai Slavov · Boston, Massachusetts
Research Focus
Dr. Nikolai Slavov's lab focuses on understanding Alzheimer's Disease (AD) by studying the abnormal and mis-processed proteins that accumulate in the brain. The research combines cutting-edge techniques in proteogenomics and mass spectrometry to analyze these proteins in different brain regions and cell types. By identifying how these proteins contribute to AD, the lab aims to uncover insights that could lead to new therapeutic targets for the disease.
Alzheimer's Diseaseproteomicstauopathymass spectrometrycell-type specific analysisproteogenomicsprotein misfoldingneurodegenerationsingle-cell analysis
Research Aims
5AIM 01Characterize abnormal proteins across multiple brain regions in Alzheimer's Disease patients.
AIM 02Profile individual neurons and non-neuronal cells from human brain tissues to understand cell-type specific protein dysfunction.
AIM 03Develop new approaches for systemic profiling of disease-associated proteins to identify therapeutic targets.
AIM 04Utilize rigorous methods for functional validation and causal inference in the context of protein misprocessing.
AIM 05Expand understanding of heterogeneity in protein dysfunctions related to Alzheimer's Disease.
Skills the Lab Values
mass spectrometryproteomicscell culturemouse modelsgenomic data analysisRNA sequencingbioinformaticsfunctional validation experimentsdata visualization in Python
Output against the department
Publications175bottom 44% of dept.156th of 278
this lab
most publishedleast published
Citations12ktop 30% of dept.84th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.