The University of Texas Medical Branch at Galveston · Microbiology & ImmunologyThe Macrophage Initiative
Janice J Endsley · Galveston, Texas
Research Focus
Dr. Janice J. Endsley's lab at the University of Texas Medical Branch in Galveston focuses on understanding how certain immune cells called macrophages respond to lung infections, particularly those caused by Mycobacterium tuberculosis (the bacterium that causes tuberculosis). By studying the role of specific proteins in these cells, the lab investigates how infections and conditions like HIV can affect the immune response and inflammation. The goal is to find new ways to enhance immune function and improve treatment strategies for tuberculosis and related infections.
C-type lectinsmacrophagesMycobacterium tuberculosisHIVimmune metabolisminflammationlipid metabolismMGLPPAR pathwaysco-infections
Research Aims
3AIM 01Identify the role of C-type lectin MGL in the lipid response of macrophages after Mycobacterium tuberculosis infection.
AIM 02Demonstrate how MGL pathways influence macrophage polarization in response to mycobacteria.
AIM 03Investigate the mechanisms by which MGL signaling regulates inflammation in lung macrophages during infections.
Skills the Lab Values
mass spectrometry imagingspatial transcriptomicslipidomicsflow cytometrycell culturegene deletion techniquesin vivo experimentsmetabolic assaysimmunological assaysdata analysis
Output against the department
Publications117bottom 44% of dept.268th of 486
this lab
most publishedleast published
Citations1.9kbottom 12% of dept.428th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.