Harvard University · Microbiology & ImmunologyFortune Lab
Sarah Fortune · Cambridge, Massachusetts
Research Focus
Dr. Sarah Fortune's lab focuses on understanding how the bacterium Mycobacterium tuberculosis (Mtb) develops resilience to antibiotics, leading to treatment failures. The team investigates the genetic and molecular mechanisms that allow Mtb to survive antibiotic exposure and recover more effectively than usual. Ultimately, the lab aims to inform better treatment strategies for tuberculosis and enhance public health outcomes.
antibiotic resilienceMycobacterium tuberculosispopulation genomicsdrug resistancetranscriptional regulation
Research Aims
3AIM 01Define the regulatory response of Mtb under drug exposure.
AIM 02Investigate the functions of transcription factors involved in antibiotic resilience.
AIM 03Test the role of resilience mutations in Mtb using mouse models.
Skills the Lab Values
molecular cloningcell culturebiochemical assaysgenetic engineeringmouse modelspopulation genomicsRNA sequencingWestern blottingdata analysis using Python
Output against the department
Publications246top 24% of dept.114th of 486
this lab
most publishedleast published
Citations21ktop 19% of dept.90th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.