Duke University · NeuroscienceCRB1 Research Laboratory
Jeremy N Kay · Durham, North Carolina
Research Focus
Dr. Jeremy N Kay's lab at Duke University focuses on understanding the role of the CRB1 gene in inherited retinal degeneration. By studying how different variants of the CRB1 gene affect retinal health, the lab aims to develop strategies for gene therapy that could halt or reverse vision loss in patients suffering from this condition. Their research involves complex mouse models and various cellular analyses to explore potential therapeutic interventions.
CRB1 generetinal degenerationgene therapymouse modelscellular analysis
Research Aims
3AIM 01Determine the contribution of specific Crb1 isoforms to disease-related phenotypes.
AIM 02Evaluate how each Crb1-expressing cell type contributes to disease pathology.
AIM 03Develop strategies for rescuing disease-related phenotypes through isoform-specific re-expression in photoreceptors.
Skills the Lab Values
molecular biology techniquesmouse strain generationelectrophysiologybehavioral assaysgene expression analysis
Output against the department
Publications65bottom 17% of dept.551st of 671
this lab
most publishedleast published
Citations3.9kbottom 29% of dept.474th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.