Ohio State University-Main Campus · NeuroscienceWFS1 Insight Lab
Hongjun Fu · Columbus, Ohio
Research Focus
The research lab of Dr. Hongjun Fu at Ohio State University focuses on understanding the mechanisms behind neuronal vulnerability in Alzheimer's disease, particularly regarding a protein called WFS1. They explore how deficiencies in this protein contribute to the accumulation of toxic tau proteins in neurons, leading to cognitive decline. By studying the pathways involved, they aim to uncover potential therapeutic targets for treating and preventing neurodegenerative diseases.
Alzheimer's DiseaseWFS1tau pathologyneurodegenerationautophagy
Research Aims
3AIM 01Investigate the role of WFS1 in tau clearance and neurodegeneration.
AIM 02Elucidate the molecular signatures of neurons vulnerable to tau pathology.
AIM 03Determine how WFS1 deficiency impacts cognitive functions in Alzheimer's disease.
Skills the Lab Values
cell culturemouse modelsRNA sequencingWestern blotco-immunoprecipitation
Output against the department
Publications125bottom 44% of dept.371st of 671
this lab
most publishedleast published
Citations5.3kbottom 38% of dept.414th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.