University of Iowa · Microbiology & ImmunologyEllermeier Cell Biology Lab
Craig D Ellermeier · Iowa City, Iowa
Research Focus
Dr. Craig D Ellermeier's lab at the University of Iowa focuses on the bacterium Clostridioides difficile, which is responsible for serious gut infections. His research aims to understand how this bacterium assembles its protective cell envelope, which could help develop targeted antibiotics that don't harm beneficial gut bacteria. The lab uses various techniques, including genetics and microscopy, to investigate the unique features of C. difficile and its resistance to treatments.
Clostridioides difficilebacterial infectioncell envelope biogenesisantibiotic resistanceCRISPR interferencegenetic regulationpeptidoglycan synthesispublic health
Research Aims
5AIM 01Investigate the enzymes responsible for cell wall crosslinking in C. difficile.
AIM 02Utilize CRISPR interference to identify essential genes in cell envelope biogenesis.
AIM 03Analyze the regulation of unique crosslinking in the cell wall of C. difficile.
AIM 04Explore the impact of the cell envelope structure on antibiotic resistance.
AIM 05Develop novel targets for antibiotic development against C. difficile.
Skills the Lab Values
genetic manipulationfluorescence microscopyCRISPRbiochemical assaysbacterial culturegene expression analysiscell wall analysisprotein characterization
Output against the department
Publications62bottom 16% of dept.405th of 486
this lab
most publishedleast published
Citations3.0kbottom 21% of dept.383rd of 486
this lab
most citedleast cited
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