Columbia University in the City of New York · PhysiologyIon Channel Regulation Lab
Manu Ben Johny · New York, New York
Research Focus
Manu Ben Johny's lab at Columbia University focuses on understanding the function and regulation of ion channels in neurons and cardiomyocytes. Their research aims to explore novel mechanisms, such as the role of palmitoylation in calcium channels and the regulation of sodium channels by fibroblast growth factor homologous factor (FHF), to develop new therapeutic strategies for neurological diseases and cardiac arrhythmias.
ion channelspalmitoylationcardiac arrhythmiasneurological diseaseschannel modulationsodium channelsCaV channelsFHF regulationchronic pain
Research Aims
5AIM 01Investigate the physiological role of S-palmitoylation in CaV2.1/2.2 channels.
AIM 02Develop engineered depalmitoylases for targeted modulation of calcium channels.
AIM 03Understand the regulatory mechanisms of late Na current in cardiac cells.
AIM 04Identify the isoform-specific effects of FHF on NaV1.5 channels.
AIM 05Engineer peptide inhibitors to modulate late Na current in cardiomyocytes.
Skills the Lab Values
electrophysiologymolecular cloningcell cultureconfocal imagingFRET assaysPCRWestern blottingviral manipulationmouse modelsdata analysis
Output against the department
Publications122bottom 36% of dept.181st of 286
this lab
most publishedleast published
Citations2.3kbottom 15% of dept.244th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.