Yale University · Microbiology & ImmunologyLiu Lab
Jun Liu · New Haven, Connecticut
Research Focus
The lab of Dr. Jun Liu at Yale University focuses on understanding how certain bacteria, particularly Helicobacter pylori and spirochetes, manage to move and infect hosts. By studying unique structures called sheathed flagella, which help these bacteria navigate their environments, the lab aims to uncover new ways to combat infections linked to diseases like ulcers and Lyme disease. The research combines advanced imaging techniques with genetic and biochemical methods to reveal insights that could lead to new antibacterial therapies.
Helicobacter pylorispirochetesflagellar motilitybacterial pathogenesisantibacterial targets
Research Aims
3AIM 01Investigate how sheathed flagella in H. pylori aid in motility and immune evasion.
AIM 02Characterize the accessory proteins involved in flagellar assembly and function.
AIM 03Understand the structure and function of periplasmic flagella in spirochetes.
Skills the Lab Values
cryogenic electron tomographyin-situ electron microscopybacterial geneticsbiochemical assaysmolecular biology techniques
Output against the department
Publications1,025top 1% of dept.5th of 486
this lab
most publishedleast published
Citations22ktop 18% of dept.86th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.